Yep, it was 30 years ago this week I started medical school, and boy, if I knew then what I know now, would I have finished? Hindsight is 20/20, but, foresight is infinite, when it is on the money. Over at 1boringoldman.com, the author there continues to rail away about Paxil and the infamous Study 329 and how SmithKlineBeecham suckered everyone in sight getting Paxil approved for use in C & A patients.
First a little explanation, as best by Wikipedia,
The best summation? “Led by Martin Keller, then professor of psychiatry at Brown University, study 329 became controversial because the article that reported the trial results – in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) in 2001 – was ghostwritten by a PR firm hired by the drug company and downplayed the trial’s negative findings.
The study had failed to show efficacy for paroxetine in adolescent depression, something SmithKline Beecham acknowledged internally in 1998.[n 1] In addition there had been more examples of suicidal thinking and behaviour in the group taking paroxetine.[n 2] Although the article included these negative results, it did not account for them in its conclusion. On the contrary, it concluded that paroxetine is “generally well tolerated and effective for major depression in adolescents.” The company relied on the article to promote paroxetine for off-label use in teenagers.[n 3] “
The latest from 1BOM about it:
Yes, I commented in the thread, and I ended it as the author closed the thread after me, and here is what I wrote:
Hey, it is what it is, any regular reader here know that, I would hope. Anyway, I decided to write this post tonight, Saturday at 10PM although Word Press goes 5 hours ahead so the date here is Sunday the 23rd, as I read the most recent issue of The Week magazine and found it to be just a rehash of endless examples of personality disorder run amok in America and even internationally, but, the talking points page (pg14) had something just pathetic to read.
Titled “College: A threat to mental health”, it was a summation of how students are being hijacked by not only the colleges who are just looking to profit on these students 4, 5, even 6 year tracks to get just a Bachelor’s degree, but, students even being hijacked by themselves. The summation starts with Greg Lukianoff and Jonathan Haidt’s piece in The Atlantic:
I like the end of the first paragraph in The Week about the article: “What’s at stake here is not only academic freedom but also college students’ “mental health”. You think, when some students think their sole opinions trump those of the majority student body? Seems eerily familiar with what some of these Presidential candidates are spewing daily?? And to think these students can vote…
Anyway, next paragraph talks of one professor’s point about trying to worry about having to provide trigger warnings to not upset his students. Gee, how nice.
Last paragraph of the review, you can google Daniel Drezner in the Washington Post to read the point about what colleges are getting away with their inflated tuition rates. Anyone reading here about to put a child into college, well, I just finished my two rounds, so I feel your pain…
Where is the relation of the failures of Big Pharma to students’ low threshold for pain? Ironic it is, what I see with some regularity these days, some adult patients coming in for instant relief of their depression or anxiety, and having zero tolerance for not feeling better in a few weeks. You see, part of why the Paxil study got away with the lies and misleading conclusions started with the parents, who wanted their kids on meds and I would bet that a lot of these teens did not participate in much psychotherapy in that study, but, I didn’t read the full methods section, so my bad if I was wrong on that assumption. Fast forward to now, and what do we have, more kids expecting everything and not having to endure any pain or discomfort.
Like, their parents as well?
Anyway, back to the top, I don’t get what is to be resolved by beating this dead horse of Study 329, but, that is someone else’s blog, and I hope it gets the resolution the author and regular commenters pine away with every post about it. Me, I want bad things to happen to the bad guys, and frankly, pleasant and respectful discussion only feeds into the characterologically disordered cretins that continue to get away with bad things. And I know, what will I accomplish with this paltry blog?
Well, I’ll leave any interested reader with this observation about character. Pay attention to those around you and see if people you respect and admire do the following three simple things with regularity:
Use a blinker when they change lanes on the road?
Open a door for someone behind them who is in need?
Let someone with just 1 or 2 items go in front when in line for a purchase?
My guess is over 2/3s of politicians never do the above, most psychiatrists with a profit motive also are inattentive to these intrinsic respects, and, in general, most personality disordered people in the communities we live, well, they read the above and might actually say outloud, “who cares” or “what’s your point?”
The whole point of this post comes down to character, and boy, do we lack it as a culture these days. What is the real shame are the people who come into the office who do know better and intrinsically have decent character, and see they are becoming obsolete in their communities. Yeah, that is sad and creates some sense of doom in those who are trying to make sense of the senseless.
Like, trying to litigate Study 329 these days. Hey physician colleagues, would you have gone to Medical School if you knew then what you know now?
Watch that coming 2 X 4 at your head in seeking hindsight…
Summer is almost over, what will Fall bring? Should I ask?